Year: 2018 | Month: August | Volume 8 | Issue 4
Effect of Zinc Supplementation on Oxidative Stress status in Male Wistar Rats
Abstract:
The study was conducted on 72 weaned Wistar male rats which were divided into 3 groups viz. control, T1 and T2. Control rats were given diet without zinc supplementation while the rats of T1 and T2 groups were given diet containing zinc sulphate @ 50 mg and 100 mg/kg body weight/day, respectively for 8 weeks from 4 to 12 weeks of age. Blood samples were collected on 6, 8, 10 and 12 weeks of zinc supplementation and oxidative parameters were studied. Oxidative indices viz super-oxide dismutase (SOD), glutathione peroxidise (GPx), glutathione-s-transferase (G-s-T), catalyse (CAT) and lipid peroxidise (LPO) showed decreasing trend in T1 group, whereas increasing trend was observed in T2 group as age advanced; no such increasing or decreasing trend observed in control, except LPO activities, which showed increasing trend with advancing age. Zinc @ 50 mg/kg body weight/day (T1) proved better choice than zinc @ 100 mg/kg body weight/day (T2) in reducing oxidative stress in growing rats.
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